On 20-21th November 2019, the 11th National Clinical Immunology Symposium (NACLIS 11) and 2nd International Conference on Primary Immunodeficiency were held at the Teaching Hospital, Universiti Putra Malaysia. The events were mainly organised by Malaysian Society of Allergy and Immunology (MSAI) with the collaboration of Universiti Putra Malaysia (UPM), Malaysian Patient Organisation for Primary Immunodeficiencies (MyPOPI), Advanced Medical and Dental Institute (AMDI), Universiti Sains Malayisa (USM), and International Patient Organisation for Primary Immunodeficiency Diseases (IPOPI). Among the participants invited were delegates from Ministry of Health Malaysia (MOH), universities, Institute of Medical Research Malaysia and health practitioners from private practices in Malaysia. The informative itineraries include sharing session with PID patients, PID in Malaysia Through 4 Decades: A Pre 2020 Awakening, Transition Care of PID: From Paediatric to Adult, PID Diagnostic Service in Malaysia and Its Dilemma.